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Multiple Choice

Which disease has an age range of 15-30 and is more likely to affect men?

Age of onset and sex distribution are strong clues when considering inflammatory conditions of the spine. Ankylosing spondylitis typically begins in late adolescence to early adulthood and is more common in men, which matches the 15–30 age range and male predominance described. It presents with inflammatory back pain that is worse with rest and improves with activity, morning stiffness, and can progress to sacroiliitis and reduced chest expansion. Extra-articular features like uveitis can also occur, reinforcing the inflammatory spine pattern. Gout and gallstones usually present later in life and don’t fit the young male pattern as well, while osteoid osteoma occurs in younger individuals (often teens to early twenties) as a solitary bone lesion with localized pain, not the classic inflammatory back pain of AS. Thus the age range and gender pattern point to ankylosing spondylitis as the best fit.

Age of onset and sex distribution are strong clues when considering inflammatory conditions of the spine. Ankylosing spondylitis typically begins in late adolescence to early adulthood and is more common in men, which matches the 15–30 age range and male predominance described. It presents with inflammatory back pain that is worse with rest and improves with activity, morning stiffness, and can progress to sacroiliitis and reduced chest expansion. Extra-articular features like uveitis can also occur, reinforcing the inflammatory spine pattern.

Gout and gallstones usually present later in life and don’t fit the young male pattern as well, while osteoid osteoma occurs in younger individuals (often teens to early twenties) as a solitary bone lesion with localized pain, not the classic inflammatory back pain of AS. Thus the age range and gender pattern point to ankylosing spondylitis as the best fit.